from machine import Pin
import time

switch = Pin(1, Pin.IN, Pin.PULL_UP)

last_press = 0

def irq(pin):
    global last_press

    now = time.ticks_ms()

    if time.ticks_diff(now, last_press) < 50:
        return

    last_press = now

    print("PRESS")

switch.irq(
    trigger=Pin.IRQ_FALLING,
    handler=irq
)